What Is Nexlizet? Nexlizet (bempedoic acid and ezetimibe) contains an adenosine triphosphate-citrate lyase (ACL) inhibitor and a cholesterol absorption inhibitor and is used as an adjunct to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease who require additional lowering. Key Takeaways New LDL cholesterol treatment guidelines from the ACC, AHA and peer organizations recommend earlier screening and treatment, including adding Amgen’s and Regeneron/Sanofi’s PCSK9 inhibitors and Esperion’s Nexletol (bempedoic acid) and Nexlizet to statins. Concomitant use of NEXLIZET or NEXLETOL with greater than 20 mg of simvastatin or 40 mg of pravastatin should be avoided due to the potential for increased risk of simvastatin- or pravastatin-related myopathy. Concomitant use with fibrates may increase triglycerides and decrease high-density lipoprotein cholesterol. What is Nexlizet? Nexlizet is a prescription medicine that contains 2 cholesterol lowering medicines, bempedoic acid and ezetimibe. Nexlizet is used along with diet and other lipid-lowering medicines in the treatment of adults with: heterozygous familial hypercholesterolemia (HeFH). Nexlizet reduces cholesterol by decreasing the amount made by your liver and increasing the breakdown of bad cholesterol. It also inhibits the absorption of cholesterol in the intestines. Nexlizet is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat adults with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease who require additional lowering of low-density lipoprotein cholesterol (LDL-C). Nexlizet should be used in addition to dietary changes. Nexlizet is not a statin, does not contain a statin, but it can be used together with a statin. Nexlizet has a dual mechanism of action. The bempedoic acid component lowers LDL-C blood levels by blocking an enzyme involved in the production of cholesterol by the liver. NEXLIZET is a prescription medicine that contains 2 cholesterol-lowering medicines, bempedoic acid and ezetimibe. NEXLIZET is used along with diet and exercise to reduce low-density lipoprotein (LDL, or bad cholesterol) in adults with high blood cholesterol levels called hypercholesterolemia, including a type of high cholesterol called. Description Bempedoic acid and ezetimibe combination is used together with diet and other cholesterol-lowering medicines to reduce bad cholesterol (LDL) in patients with primary hyperlipidemia (high blood cholesterol), including heterozygous familial hypercholesterolemia (HeFH). Bempedoic acid and ezetimibe combination is also used to lower the risk of heart attack and heart procedures (eg. INDICATION NEXLIZET is indicated as an adjunct to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease who require additional lowering of LDL-C.